Vacation can refer to:

• time off from work, also referred to by the Anglocentric term holiday.
• an e-mail autoresponder
• National Lampoon's Vacation, a 1983 film
• Vacation, a song/album by the Go-Go's
• The Vacation, a band
• The Sims: Vacation, a 2002 expansion pack of The Sims
• "Vacation" is a Rugrats hour long special
• "V-A-C-A-T-I-O-N", a song recorded by Connie Francis
• Vacation (Young Jeezy song)

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